![]() ![]() Polycyclic aromatic compounds (PACs), of which polycyclic aromatic hydrocarbons (PAHs) are a subset, include both all-carbocyclic as well as mixed carbo- and heterocyclic subunits. ![]() The late-stage and de novo creation of multiple arenes in these multi-benzyne processes constitutes a fundamentally new synthetic strategy for constructing novel molecular topologies. More specifically, these all conform to processes that can be considered as radial-hexadehydro-Diels-Alder (HDDA) reactions. This produces topologically unique products through sequential generation/trapping of a series of benzyne intermediates. Here we describe one-pot, purely thermal cyclizations of substrates containing sets of independent triynes, each arrayed upon a common core structure. Given the unabated interest in such molecules, the development of new methods and strategies for the practical synthesis of PACs having new structural motifs is important. In modern decades these have attracted ever-growing attention because of their architectures, properties, and wide-ranging practical applications (cf. Polycyclic, highly fused and, perforce, highly conjugated aromatic organic compounds (PACs) have been of interest to chemists since the discovery of naphthalene in 1821. ![]()
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